Neuronal activity enhances tau propagation and tau pathology in vivo
By Jessica W. Wu, S. A. Hussaini, I. M. Bastille, Gustavo A. Rodriguez, Ana Mrejeru, K. Rilett, David W. Sanders, C. Cook, H. Fu, R. Boonen and 8 more. Nature Neuroscience, 2016
744 citations recorded by the source corpus.
Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to explain the progressive spread of tauopathy observed in the brain of patients with Alzheimer's disease. Here we show that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space. Neuronal activity has been shown to regulate tau secretion, but its effect on tau pathology is unknown. Using optogenetic and chemogenetic approaches, we found that increased neuronal activity stimulates the release of tau in vitro and enhances tau pathology in vivo. These data have implications for disease pathogenesis and therapeutic strategies for Alzheimer's disease and other tauopathies.
Subfields: Cellular and Molecular Neuroscience, Physiology
View Paper: https://www.semanticscholar.org/paper/b91f548ddf52712c351eb35f20ef561e5c334df9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Physiology
Citations in the corpus
- The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans (2019, background): “When neuronal activity is increased chronically, it can increase tau propagation and pathology (10).”
- Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “As expected, increased neuronal activity is shown to promote both physiological and pathological release of tau in vitro, and exacerbates tau pathology in vivo [257, 258].”