Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence.

By Jochen R. Guck, Stefan Schinkinger, B. Lincoln, Falk Wottawah, Susann Ebert, Maren Romeyke, D. Lenz, Harold M. Erickson, R. Ananthakrishnan, Daniel Mitchell and 3 more. Biophysical Journal, 2005

1,440 citations recorded by the source corpus.

Subfields: Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/b8fe183fb0281cef778f9f75b04bed456378ffd8

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In Materials Chemistry

1. Diana Lechtman-Goldstein
2. Michael L. Roukes
3. John F. McDonald
4. Daphne Weihs
5. N. Gal
6. Chang Q. Sun

Citations in the corpus

• Particle tracking in living cells: a review of the mean square displacement method and beyond (2013, methodology): “cal stretcher (Guck et al. 2005), microfluidics devices (Hou et al.”
• Review on Cell Mechanics: Experimental and Modeling Approaches (2013, methodology): “…used as a tool for probing whole-cell mechanical properties of red blood cells [172] [173] [174] [175] [176] [177] [178], fibroblasts [179] [180] [181], tumor cells [177] [181], chondrocytes/osteoblasts [182] [183] [184], epithelial cells [181], mesenchymal stem cells [185], optical tweezers…”
• A tense situation: forcing tumour progression (2009, background): “1 ) and that each cellular component within a tissue has a unique rheology and a stiffness optimum that can change over the course of development (as in lung branching morphogenesis), in response to function (as during mammary gland lactation) or in pathological situations (as in atherosclerotic p”
• Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells (2012, methodology): “3 and Table 2, are consistent with previous reports linking cellular deformability with tumorgenic and metastatic potential [5,7,33].”
• Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “The stiffness of the extracellular matrix surrounding tumors as well as the mechanics of the tumor mass itself, mostly determined by actomyosin cytoskeleton dynamcis, has also been shown to be different from normal tissue (106, 271).”
• Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “For instance, nuclear softening, which can occur in cancer cells (Cross et al., 2007; Guck et al., 2005), would promote nuclear flattening in response to force and subsequent YAP nuclear import.”
• Three-dimensional holographic optical manipulation through a high-numerical-aperture soft-glass multimode fibre (2018, background): “The first systems capable of one-dimensional manipulation were realised in counter-propagating dual-fibre schemes [20, 21], and later, by exploitation of few-mode fibres, enabled the controlled rotation of cells [22, 23].”
• Cell mechanics: integrating cell responses to mechanical stimuli. (2007, background): “This finding suggests that cells may work to maintain a tightly controlled rigidity under specific conditions, and therefore, deviations from a normal range of stiffness might be used to identify abnormal cells (20).”
• Hydrodynamic stretching of single cells for large population mechanical phenotyping (2012, background): “Single-cell platforms that can assay this heterogeneity include micropipette aspiration (5), atomic force microscopy (AFM) (3), magnetic bead-based rheology, microfluidic optical stretching (2, 14), and microfluidic cell transit analyzers (12, 15–17).”
• The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, positive): “Biophysical measurements that compare the mechanical properties of normal and cancer cells have consistently shown that cancer cells are softer than normal cells and that this cellular compliance correlates with an increased metastatic potentia”
• A bottom-up approach to cell mechanics (2006, background): “At the same time, the overall cell stiffness has been demonstrated to be very sensitive to cytoskeletal dysfunction, a connection that lends itself to an extremely efficient and reliable automated detection (and may possibly also be the cause) of some disease”