Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs

By S. Nugent, Devinder Kumar, D. Rampton, D. Evans. Gut, 2001

702 citations recorded by the source corpus.

Subfields: Gastroenterology, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/b8eebd30ee7780bdcac68bd338123597ce62d98f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. S. Duncan

In Genetics

1. H. Flint
2. S. Duncan
3. P. Louis

In Surgery

1. S. Duncan
2. M. Bergstrand

Citations in the corpus

• Two Routes of Metabolic Cross-Feeding between Bifidobacterium adolescentis and Butyrate-Producing Anaerobes from the Human Gut (2006, background): “0 as a result of active microbial fermentation of certain dietary substrates (6, 36).”
• Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “Commonly recommended standard therapies for IBD-UC patients are corticosteroids [17], amino-salicylates [18,19], and immunosuppressive agents [20,21].”
• Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics (2017, background): “As it has been reported that ulcerative colitis (UC) and CD patients often have acidic stools (Nugent et al., 2001; Barkas et al., 2013), it remains to be demonstrated whether or not local pH in the gut is modulating F.”
• The role of pH in determining the species composition of the human colonic microbiota. (2009, positive): “Several studies have used telemetry to show that the pH of the human proximal colon is generally slightly lower than that of the distal colon and faeces where the pH is closer to neutrality (Bown et al., 1974; Macfarlane et al., 1992; Nugent et al., 2001).”
• Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota (2015, neutral): “Ahuman colon was replicated by using a custom-built reactor (Marcus et al. , 2013), which represented conditions inside a proximal colon (Nugent et al. , 2001).”
• Understanding the effects of diet on bacterial metabolism in the large intestine (2007, background): “Thus, the pH of the proximal colon can become mildly acidic, increasing towards neutral pH in the distal region (Nugent et al. 2001).”
• PBPK models for the prediction of in vivo performance of oral dosage forms. (2014, background): “0 (Diakidou et al., 2009; Nugent et al., 2001).”
• pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon (2005, background): “Several reports indicate that a slightly acidic pH can occur in the proximal colon, increasing distally (4, 38, 46).”