Cancer prevention by tea: animal studies, molecular mechanisms and human relevance

By Chung S. Yang, Xin Wang, Gang Lu, Sonia C. Picinich. Nature Reviews. Cancer, 2009

1,118 citations recorded by the source corpus.

Extracts of tea, especially green tea, and tea polyphenols have been shown to inhibit the formation and development of tumours at different organ sites in animal models. There is considerable evidence that tea polyphenols, in particular (−)-epigallocatechin-3-gallate, inhibit enzyme activities and signal transduction pathways, resulting in the suppression of cell proliferation and enhancement of apoptosis, as well as the inhibition of cell invasion, angiogenesis and metastasis. Here, we review these biological activities and existing data relating tea consumption to human cancer risk in an attempt to understand the potential use of tea for cancer prevention.

Subfields: Applied Microbiology and Biotechnology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/b8dcc19f9551672851f5a1177190a120fbaf28f6

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In Applied Microbiology and Biotechnology

1. H. Mukhtar
2. N. Khan

In Oncology

1. Ping Gao
2. Huafeng Zhang
3. Linchong Sun

In Pathology and Forensic Medicine

1. N. Khan
2. H. Mukhtar
3. R. Elias

Citations in the corpus

• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “The identification of small nonnucleoside DNMT inhibitors such as flavonoids (or bioflavonoids, such as epigallocatechin-3-gallate (EGCG)) (Galeotti et al., 2008; Yang et al., 2009; Singh et al., 2011), hydralazine (Chuang et al.”
• Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update (2017, background): “One specific polyphenol, epigallocatechin-3-gallate, has shown promise as a chemopreventive agent by inhibiting enzymatic activities, cell invasion, angiogenesis, and metastasis [85].”
• The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention (2010, background): “Tea (Camellia sinensis, Theaceae) is second only to water in terms of worldwide popularity [1].”
• Tea Polyphenols in Promotion of Human Health (2018, background): “One cup of green tea contains up to 200 mg of EGCG, which has been shown to have chemopreventive/chemotherapeutic effects against several types of cancers [2,3].”