Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart

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Eph receptors and ephrins in cancer: bidirectional signaling and beyond (2010, background): “For example, many of the differences observed in Eph–ephrin signalling outcomes may relate to differences in spatial and temporal coordination of input signals and relays, and so vary between cell types as well as in vitro and in vivo environment”
3did: a catalog of domain-based interactions of known three-dimensional structure (2013, background): “Given the smaller interface, DMIs are often weaker in nature and thus often used in transient associations such as signaling networks (28).”