Eph receptors and ephrins in cancer: bidirectional signaling and beyond
By E. Pasquale. Nature Reviews. Cancer, 2010
1,225 citations recorded by the source corpus.
The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Eph receptors and ephrins have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumour growth, invasiveness, angiogenesis and metastasis in vivo. However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2cdf3194c106424e9862fdd72369a3381318b33c
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In Molecular Biology
Citations in the corpus
- Anoikis: an emerging hallmark in health and diseases (2012, background): “In analogy with the acquisition of anoikis resistance induced by EMT, EphA2, which is over-expressed in many types of cancer [112], also confers resistance to anoikis through the action of the guanine nucleotide exchange factor Ephexin4, PI3K and Akt [113].”
- Hallmarks of cancer: the next generation. (2011, neutral): “These newly characterized pathways have been functionally implicated in developmental and tumor-associated angiogenesis and illustrate the complex regulation of endothelial cell phenotypes (Pasquale, 2010; Ahmed and Bicknell, 2009; Dejana et al., 2009; Carmeliet and Jain, 2000).”