Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis

By Natalia N. Ivanova, A. Sorokin, I. Anderson, N. Galleron, Benjamin Candelon, V. Kapatral, A. Bhattacharyya, G. Reznik, Natalia Mikhailova, Alla L. Lapidus and 13 more. Nature, 2003

869 citations recorded by the source corpus.

Bacillus cereus is an opportunistic pathogen causing food poisoning manifested by diarrhoeal or emetic syndromes. It is closely related to the animal and human pathogen Bacillus anthracis and the insect pathogen Bacillus thuringiensis, the former being used as a biological weapon and the latter as a pesticide. B. anthracis and B. thuringiensis are readily distinguished from B. cereus by the presence of plasmid-borne specific toxins (B. anthracis and B. thuringiensis) and capsule (B. anthracis). But phylogenetic studies based on the analysis of chromosomal genes bring controversial results, and it is unclear whether B. cereus, B. anthracis and B. thuringiensis are varieties of the same species or different species. Here we report the sequencing and analysis of the type strain B. cereus ATCC 14579. The complete genome sequence of B. cereus ATCC 14579 together with the gapped genome of B. anthracis A2012 enables us to perform comparative analysis, and hence to identify the genes that are conserved between B. cereus and B. anthracis, and the genes that are unique for each species. We use the former to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b880abf2ab450a757d0eec503235d21394074552

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In Genetics

Silvia G. Acinas

In Molecular Biology

Citations in the corpus

Main Groups of Microorganisms of Relevance for Food Safety and Stability (2017, neutral): “Most studies related to genomic analysis have indicated that B. cereus is specialized on protein metabolism; therefore, this fact suggests that it has adapted toward a symbiotic or parasitic life cycle (Ivanova et al., 2003; Stenfors Arnesen, Fagerlund, & Granum, 2008).”
Increasing biological complexity is positively correlated with the relative genome-wide expansion of non-protein-coding DNA sequences (2003, neutral): “zae Rd 0.15 4553 4524893 [102] Bacillus halodurans 0.152 4066 4202353 [95] Xanthomonas campestris 0.157 2708 5076187 [101] Bacillus anthracis 0.159 5842 5370060 [103] Bacillus cereus 0.16 5366 546909 [104] Buchnera aphidicola (Bp) 0.164 553 618000 [105] Staphylococcus aureus N315 0.165 2595 2813641 ”
Low Concentrations of Bile Salts Induce Stress Responses and Reduce Motility in Bacillus cereus ATCC 14570 (2007, background): “ranging from locus BC1625 to locus BC1671 (38).”
Divergence and Redundancy of 16S rRNA Sequences in Genomes with Multiple rrn Operons (2004, methodology): “... Firmicutes 9 and 10 Bacillus anthracis Firmicutes 10 and 11 Bacillus cereus Firmicutes 9, 12, and 13 Staphylococcus aureus Firmicutes 5 and 6 Enterococcus faecium Firmicutes 5 and 6 Streptococcus agalactiae Firmicutes 6 and 7 Streptococcus pyogenes Firmicutes 5 and 6 a Data were obtained from th”
Purification and characterization of chitosanase from Bacillus cereus D-11 (2008, neutral): “cereus ATCC 14579 (Ivanova et al., 2003) and Bacillus sp.”
From soil to gut: Bacillus cereus and its food poisoning toxins. (2008, background): “…the B. cereus type strain ATCC 14579 and from B. anthracis suggested that their metabolic capacity is more adapted to the use of proteins as a nutrient source than carbohydrates, and furthermore that genes for establishment within a host were conserved (Ivanova et al., 2003; Read et al., 2003).”
Molecular basis of bacterial resistance to chloramphenicol and florfenicol. (2004, background): “In addition, annotations of cat genes were found in the whole genome sequences of Rhodobacter capsulatus [18], Mesorhizobium loti [19], S. agalactiae strain 2306 [20], Bacillus cereus [21], and Brucella melitensis [22].”