Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection.

By Yuki Takahashi, M. Nishikawa, Haruka Shinotsuka, Yuriko Matsui, Saori Ohara, Takafumi Imai, Y. Takakura. Journal of Biotechnology, 2013

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Biodistribution and Delivery Efficiency of Unmodified Tumor-Derived Exosomes (2014, result): “Regardless, our results demonstrate the rapid uptake of exosomes by the liver and spleen, consistent with previous reports examining the biodistribution of exosomes [20, 22, 23].”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, neutral): “5–3 min [140,200–202].”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “F o r p er so n al u se o n ly . was not confirmed by direct analysis of the half-life of EVs in blood after intravenous injection: Two recent studies using tumor-derived EVs exposing a membrane-bound luciferase fused to the C1C2-domain of MFGE8/lactadherin (Takahashi et al. 2013), or biotinylated s”
Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment (2018, neutral): “This is particularly important as the constitutive production and delivery of drug-encoding mRNAs inside exosomes may overcome the challenges associated with the limited half-life of exosomes administered intravenously 51 .”
Engineering exosomes for targeted drug delivery (2021, background): “Further examples of fusion proteins based on lactadherin designed for exosome display include Gaussia luciferase-lactadherin and streptavidin-lactadherin [66-68].”