Tertiary lymphoid structures in the era of cancer immunotherapy

By C. Sautès-Fridman, F. Petitprez, J. Calderaro, W. Fridman. Nature Reviews. Cancer, 2019

1,531 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b81a432e4976012fe07b5b406ad70dca373a2e5d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Oncology

Citations in the corpus

Neoadjuvant checkpoint blockade for cancer immunotherapy (2020, background): “chemokines or even synthetic scaffolds to induce TLS formation in otherwise “noninflamed” tumors (69).”
Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “Functionally, B cells may act as APCs for T cells, promoting local tumor-associated T cell responses.(81,82) The observation of B cell clonal expansion and immunoglobulin phenotype switching across human cancers further indicates a possible role for antibody-dependent cell-mediated cytotoxicity (ADC”
Spatially organized multicellular immune hubs in human colorectal cancer (2021, background): “, 2016), contain germinal center B cells, and have been associated with high T cell activity, favorable prognosis, and effective response to immunotherapy (Cabrita et al., 2020; Coppola et al., 2011; Helmink et al., 2020; Petitprez et al., 2020; Sautès-Fridman et al., 2019).”
Tertiary lymphoid structures in cancer (2022, background): “As discussed above, with the caveat that available studies in some cases vary with respect to themarkers used for TLS identification, there are indications for TLS heterogeneity between cancer types aswell as betweenpatients (21, 27), and work in chemokine-transgenic mouse models provides reasonable”
B cells and tertiary lymphoid structures promote immunotherapy response (2020, positive): “…understood 14,15,19-24 – with some studies suggesting that they are tumor-promoting while others show a positive association with improved cancer outcomes, particularly when they are found in association with organized lymphoid aggregates known as tertiary lymphoid structures (TLS) 12,13,16,25-27 .”