The Biophysics and Cell Biology of Lipid Droplets
By A. Thiam, Robert V Farese, T. Walther. Nature reviews. Molecular cell biology, 2013
950 citations recorded by the source corpus.
Lipid droplets are intracellular organelles that are found in most cells, where they have fundamental roles in metabolism. They function prominently in storing oil-based reserves of metabolic energy and components of membrane lipids. Lipid droplets are the dispersed phase of an oil-in-water emulsion in the aqueous cytosol of cells, and the importance of basic biophysical principles of emulsions for lipid droplet biology is now being appreciated. Because of their unique architecture, with an interface between the dispersed oil phase and the aqueous cytosol, specific mechanisms underlie their formation, growth and shrinkage. Such mechanisms enable cells to use emulsified oil when the demands for metabolic energy or membrane synthesis change. The regulation of the composition of the phospholipid surfactants at the surface of lipid droplets is crucial for lipid droplet homeostasis and protein targeting to their surfaces.
Subfields: Biochemistry, Molecular Biology, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/b7e8abd29ff78a0112f213c4208a3b5ad899f429
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In Biochemistry
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In Molecular Biology
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In Spectroscopy
Citations in the corpus
- Lipid Droplet Biogenesis (2014, positive): “Above a certain size, depending on the oil and phospholipid composition, lipid lenses in the ER are predicted to be unstable and bud, by a mechanism similar to de-wetting, due to thermal fluctuations [6] (Figure 1).”
- Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development (2014, background): “The Lipid Signature of Memory T Cells Suggests Active Lipolysis Most cells can store lipids as TAG and CE then subsequently release FA from these stores when needed (Thiam et al., 2013).”