Exploring the opioid system by gene knockout.

By Brigitte L. Kieffer, C. Gavériaux-Ruff. Progress in neurobiology, 2002

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Reward Processing by the Opioid System in the Brain (2009, neutral): “Opioid system knockout studies have previously been reviewed (128, 191), and major findings in the context of drug abuse are updated and summarized here.”
Attacking pain at its source: new perspectives on opioids (2003, background): “Opioids are the most powerful drugs for severe acute and chronic pain, but their widespread use is hampered by side effects such as depression of breathing, nausea, clouding of consciousness, constipation, addiction and toleranc”
State-dependent opioid control of pain (2004, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=18390">OPRM ), because its activation is necessary for the action of the most potent analgesic”