Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

By Deirdre Nolfi-Donegan, Andrea Braganza, S. Shiva. Redox Biology, 2020

1,230 citations recorded by the source corpus.

The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation. A consequence of electron transfer is the generation of reactive oxygen species (ROS), which contributes to both homeostatic signaling as well as oxidative stress during pathology. In this graphical review we provide an overview of oxidative phosphorylation and its inter-relationship with ROS production by the electron transport chain. We also outline traditional and novel translational methodology for assessing mitochondrial energetics in health and disease.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c3e267efb6a65a3583eb16dad503fc900789a7a

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Citations in the corpus

• Mitochondria ROS and mitophagy in acute kidney injury (2022, background): “In this process, electrons are transported through the ETC and are finally shuttled to molecular oxygen by complex IV [12].”