A synthetic multicellular system for programmed pattern formation

By Subhayu Basu, Y. Gerchman, C. Collins, Frances H. Arnold, Ron Weiss. Nature, 2005

1,180 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b7973530abd8b41d72ab47f20adb38a3867a7ec5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Christopher A. Voigt
2. Katie Brenner
3. Lingchong You
4. Nariman Farsad
5. Adam J. Rubin
6. George Pappas
7. Dana Hughes
8. Adam P. Arkin

In Cell Biology

1. Philip K. Maini
2. Eamonn A. Gaffney
3. Ruth E. Baker
4. Debashish Chowdhury

In Molecular Biology

1. Yaakov Benenson
2. Christopher A. Voigt
3. Adam J. Rubin
4. Ahmad S. Khalil
5. Frances H. Arnold
6. Howard M. Salis
7. Lingchong You
8. Katie Brenner

Citations in the corpus

• Materials that couple sensing, actuation, computation, and communication (2015, background): “Hardware demonstrations that came out of this movement include “paintable computing” (19), a distributed system of locally communicating nodes that used gradient information to display lines and simple characters; pattern formation in bacterial colonies that are receptive to chemical gradients and c”
• Engineering microbial consortia: a new frontier in synthetic biology. (2008, methodology): “Engineered acyl-HSL communication has been used in biological ‘circuits’ that coordinate population-wide behaviors ranging from population-density-dependent fluorescence [37], cell suicide [38], and invasion of cancer cells [39] to pattern formation [ 40 ].”
• Partial differential equations for self-organization in cellular and developmental biology (2008, background): “Highly amenable to mathematical modelling, pattern formation by design has broad potential application areas including tissue engineering, biosensing and bio-directed fabrication [113].”
• Electrokinetic and optical control of bacterial microrobots (2011, methodology): “This technique may enable MBR–MBR communication by using genetically programmed sender and receiver cells [39].”
• A Comprehensive Survey of Recent Advancements in Molecular Communication (2014, background): “The information particles can be generated by modifying a metabolic pathway of a biological cell, which then synthesizes and releases specific signaling molecules [75], [76].”
• A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions (2012, background): “…the field, and a variety of circuit behaviors have been implemented, including memory, oscillations, logic operations, filtering, and noise propagation (Basu et al., 2005; Becskei and Serrano, 2000; Elowitz and Leibler, 2000; Friedland et al., 2009; Gardner et al., 2000; Guet et al., 2002; Pedraza…”
• Measuring the activity of BioBrick promoters using an in vivo reference standard (2009, background): “Such libraries of characterized promoters have been shown to be valuable to researchers for tuning biochemical networks to optimize the synthesis of products of interest [20,30].”
• Refinement and standardization of synthetic biological parts and devices (2008, positive): “( Box 2 ); ad hoc engineered constructs, similar in function to BBa_F2620, have been used to control programmed pattern formation, cell culture density and gene expressio”