DNA Replication Fidelity*

By Thomas A. Kunkel. Journal of Biological Chemistry, 2004

1,079 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b75ad765e6d8fdf8b839842565859e82350b1a8b

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Citations in the corpus

A novel function of DNA polymerase ζ regulated by PCNA (2006, background): “Crick base pairs to allow efficient and accurate synthesis (Kunkel, 2004).”
Rates of evolutionary change in viruses: patterns and determinants (2008, background): “Similarly, it is uncertain what portion of the in vivo mutation rate in DNA viruses is due to polymerase error, as opposed to the differing effects of host and viral error-correction enzyme”
Viral Mutation Rates (2010, background): “additional host-mediated copying processes (50, 87), they probably contribute little to the overall mutation rate.”
Cutting Edge: DNA Polymerases μ and λ Are Dispensable for Ig Gene Hypermutation1 (2002, background): “Polymerase (pol) 4 has long been the only known nonreplicative DNA polymerase whose intrinsic fidelity, in the 10 3 range, would be compatible with the estimated mutation rate of Ig genes (4).”
Perceptions of epigenetics (2007, background): “DNA synthesis is spectacularly accurate, making only 1 'unforced' error for every 10 7 –10 8 bases copie”
Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity (2004, background): “The insertion of the correct nucleotide depends in part on Watson-Crick base pair formation, but this mechanism is not sufficient to obtain high-fidelity DNA replication (23, 30).”
Clonal hematopoiesis in human aging and disease (2019, background): “The error rate of eukaryotic DNA replication tends to be very low, except in the case where DNA mismatch repair function is compromised (10, 11) The number of replication cycles that a cell has undergone typically increases with age; therefore the number of polymerase errors also cumulatively increa”
Cancer Evolution: Mathematical Models and Computational Inference (2014, background): “The normal human point mutation rate is 10−10 per base pair per cell division (Kunkel and Bebenek 2000), and this rate is elevated in many cancers, a phenomenon termed mutator phenotype (Loeb 2001; 2011).”
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “However, it can switch its role to that of a exonuclease catalyzing the shortening of the nascent DNA by excision of the nucleotide at the growing tip of the elongating DNA [1571, 1572, 1573, 1574].”
Genetic Progression and the Waiting Time to Cancer (2007, background): “The normal mutation rate due to replication errors is in the range of 10 10 to 10 9 per nucleotide per cell per division [9].”