Phosphate regulation of vascular smooth muscle cell calcification.
By S. Jono, M. McKee, Charles E. Murry, A. Shioi, Y. Nishizawà, K. Mori, H. Morii, C. Giachelli. Circulation Research, 2000
1,436 citations recorded by the source corpus.
Subfields: Nephrology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/b723f86224556decdce5d652e36633477174b203
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In Nephrology
In Nutrition and Dietetics
Citations in the corpus
- Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. (2007, background): “Investigators have reported that higher phosphorus levels increase the propensity of mineral deposition in vascular smooth muscle cells in vitro.(34) This increased predisposition can be partly explained by increased osteopontin expression(35,36) Serum phosphorus may also directly increase vascular ”
- IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (2005, background): “Jono et al [115] demonstrated that in order to cause extraosseus calcification hyperphosphatemia required active intracellular uptake of PO4 and the de novo formation of matrix vesicles by VSCM in vitro.”
- Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. (2004, background): “Several reports have described the ability of serum phosphorus to potently stimulate the phenotypic transformation of vascular smooth muscle cells into osteoblasts capable of producing a pro-mineralizing milieu (24,25).”
- Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. (2004, background): “Bone matrix proteins are deposited in medial artery calcifications of ESRD patients, suggesting osteogenic conversion of resident VSMC, while in vitro studies have shown increased calcification and osteogenic changes in VSMC in the presence of elevated P (13,14).”
- Calcification of tissue heart valve substitutes: progress toward understanding and prevention. (2005, background): “The role in pathological mineralization of naturally occurring promineralization cofactors, such as inorganic phosphate [43], bone morphogenetic protein [44], proinflammatory lipids [35], and other substances (eg, cytokines), as well as inhibitors, is an active area of research [45].”