Structural remodeling of bacteriophage T4 and host membranes during infection initiation

By Bo Hu, W. Margolin, Ian J. Molineux, Jun Liu. 2015

232 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

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In Ecology

Torsten Schwede

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Citations in the corpus

Programmable protein delivery with a bacterial contractile injection system (2023, positive): “Phage T4 possesses six long tail fibres that extend from the baseplate complex and form reversible interactions with lipopolysaccharide molecules or outer membrane proteins on the surface of host cells 27–29 .”
How the phage T4 injection machinery works including energetics, forces, and dynamic pathway (2019, background): “1 B, IV) to fuse with the tail tube and to complete the conduit for translocating DNA into the cytoplasm (5).”
Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber (2019, background): “coli outer membrane as well as to movements occurring at a distance with other LTF pivots [26, 28].”
Contractile injection systems of bacteriophages and related systems (2018, background): “…host recognition or another environmental signal with sheath contraction (Coombs and Arisaka, 1994; Goldberg et al., 1994; Leiman et al., 2004; Hu et al., 2015) whereas the capping assembly prevents the tube from sliding out from the sheath during sheath contraction (Leiman et al., 2004).”
Target highlights in CASP13: experimental target structures through the eyes of their authors (2019, methodology): “Both phages are equipped with baseplate-attached long tail fibers (LTFs) that mediate receptor-binding through their distal tips.(64-68) We recently exploited the Salmonella-specific binding of the S16 LTF as a tool for rapid, ELISA-like detection of Salmonella contaminants in food.”
Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins. (2019, background): “Over the last decade, the molecular mechanisms of host interaction by phages and their intricate baseplate complexes have been studied intensely using cryoelectron microscopy (cryoEM) and X-ray crystallography (Bebeacua et al., 2010; Guerrero-Ferreira et al., 2019; Hu et al., 2015; Plisson et al., 2”