Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

By J. Street, M. Bao, L. Deguzman, S. Bunting, F. Peale, N. Ferrara, Hope Steinmetz, J. Hoeffel, J. Cleland, A. Daugherty and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,444 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b6a32bf9cfe26a826761c135ee684d96236d65b2

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Citations in the corpus

The biology of VEGF and its receptors (2003, background): “A recent study has shown that VEGF administration leads to enhanced blood vessel formation and ossification in models of bone damag”
Endothelial cells and VEGF in vascular development (2005, background): “VEGF also has an important role in bone-fracture healing in animal models, in part by stimulation of vascular growth in the region of the injury, but evidence also suggests that it acts on bone-forming cells themselve”
Osteogenesis and angiogenesis: the potential for engineering bone. (2008, background): “Street and colleagues (Street et al., 2000; Street et al., 2002; Ryan et al., 1999; Gerber et al., 1999) have demonstrated that the inhibition of VEGF in fractured mouse femurs results in a decrease in blood vessel invasion with a reduction in osteoclastic bone remodelling, impaired callus…”
Engineering Complex Tissues (2006, unknown): “Bone formation is dependent on VEGF signaling,(252) and the sustained delivery of VEGF from polymers can enhance bone regeneration.(242,253) Nerve and blood vessel wiring is dependent on common mechanisms,(254) and VEGF signaling may be beneficial to slow or reverse various neural diseases.”
A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2 (2016, unknown): “115 Recent evidence suggests that not only does VEGF produce angiogenesis but there is also cross-talk between VEGF and the BMP signaling pathway that plays a role in osteoblastic differentiation of MSCs. 116 Unlike BMP-2, the use of VEGF alone in bone fractures is not sufﬁcient enough to lead to…”
Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis (2008, background): “Angiogenesis is regulated by 2 pathways, a vascular endothelial growth factor (VEGF)dependent pathway and an angiopoietin-dependent pathway (Suri et al., 1996).”
Osteoblasts in prostate cancer metastasis to bone (2005, background): “Recently, however, VEGF was shown to directly promote the differentiation of primary osteoblasts in vitro”
The roles of vascular endothelial growth factor in bone repair and regeneration (2016, background): “In a mouse femur facture model, inhibition of VEGF by sFlt1 caused reduced callus volume at various stages of repair, including bone remodeling, while treatment with exogenous VEGF increased vascularity and mineral density in the calcified callus [85].”