Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.

By C. Bänziger, D. Soldini, Corina Schütt, Peder Zipperlen, G. Hausmann, Konrad Basler. Cell, 2006

757 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b65b12d884a8193e6e67de54ed97a6b762dd362e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. R. Nusse
2. Hans Clevers
3. D. Virshup

In Molecular Biology

1. R. Nusse
2. Hans Clevers
3. C. Logan
4. Jonathan Kim
5. O. Clarke
6. G. Parisi
7. F. Mancia
8. Daniela Ross

Citations in the corpus

• Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver (2015, background): “To directly test whether endothelial cell derived Wnt proteins function to maintain the precursor state of pericentral cells, we conditionally deleted Wntless (Wls), a Wnt-specific transporter molecule required for proper Wnt protein secretion[27], specifically in endothelial cells.”
• Wnt/beta-catenin signaling in development and disease. (2006, positive): “Recently, Banziger et al. (2006) and Bartscherer et al. (2006) uncovered in Drosophila another conserved gene that is essential for Wnt secretion, named wntless (wls) and evenness interrupted (evi), respectively.”
• Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN) (2019, background): “This phenomenon involves a polytopic protein known as WLS,(4) which fails to ferry WNT proteins to the extracellular space in the absence of PORCN activity (5, 6).”
• Wnt signaling and stem cell control (2008, background): “Wls is specifically required in Wnt-producing cells where, in the absence of Wls, Wnt will accumulate intracellularly and not be secreted (Banziger et al. 2006; Bartscherer et al. 2006; Franch-Marro et al. 2008; Port et al. 2008).”
• Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. (2006, background): “For instance, Wntless/Evi, a seven-pass membrane protein, plays an essential role in Wnt secretion (Banziger et al., 2006; Bartscherer et al., 2006), and a protein complex involved in intracellular membrane trafficking, called the retromer complex, participates in the long-range transport of Wnt…”
• Structural basis of WLS/Evi-mediated Wnt transport and secretion (2020, background): “Following acylation, Wnts become competent to bind in the ER to the conserved membrane transport protein variously known as Wntless (WLS), Evi, and GPR177 for transport across cellular compartments and secretion (Figure 1A) (Bartscherer et al., 2006; Bänziger et al., 2006; Coombs et al., 2010; Goodm”
• Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease (2008, background): “Wnt activity is regulated at the cell surface by different transmembrane proteins and the secretion of Wnt proteins from the cell is promoted by the recently discovered protein Wntless (Wls) (Banziger et al., 2006; Bartscherer et al., 2006).”
• Endocytosis, Signaling, and Beyond (2014, background): “…by the multispan integral membrane protein, Wntless (Wls), also known as Evi/Sprinter/GPR177, which is a specific mediator of Wnt ligand secretion and is highly conserved across evolution (Banziger et al. 2006; Bartscherer et al. 2006; Goodman et al. 2006; Fu et al. 2009; Kim et al. 2009).”