Cellular and molecular basis of wound healing in diabetes.

By H. Brem, M. Tomic‐Canic. Journal of Clinical Investigation, 2007

1,675 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/b5e1d9156ca0fa93e44e3dd5f150755af751b509

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Paul Martin
2. Jaminelli Banks
3. R. Frykberg
4. S. Eming
5. M. Tomic‐Canic
6. L. DiPietro
7. Dimitrios Baltzis
8. I. Eleftheriadou

In Genetics

1. R. Frykberg
2. Jaminelli Banks
3. Paul Martin
4. S. Eming
5. M. Tomic‐Canic
6. G. Han
7. R. Ceilley

In Rehabilitation

1. Paul Martin
2. R. Frykberg
3. Jaminelli Banks
4. S. Eming
5. M. Tomic‐Canic
6. L. DiPietro
7. G. Han
8. R. Ceilley

Citations in the corpus

• Recent advances on the development of wound dressings for diabetic foot ulcer treatment--a review. (2013, background): “In general, these chronic, non-healing neuropathic foot ulcers occur in around 15% of all the diabetic population [56] and are responsible for huge medical costs as well as significantly affecting patients’ quality of life [35,56,58].”
• Factors affecting wound healing (2010, background): “DFUs are a serious complication of diabetes, and precede 84% of all diabetesrelated lower leg amputations (Brem and Tomic-Canic, 2007).”
• Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process (2017, background): “The resulting wound hypoxia typify the poor wound healing observed in diabetic patients, particularly those with diabetic foot ulcers (DFU) (1).”
• Wound repair and regeneration: Mechanisms, signaling, and translation (2014, positive): “Inadequate local angiogenesis is considered a very likely contributor to the impaired healing of DFUs (3).”
• Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro (2015, background): “In contrast, chronic nonhealing wounds exhibit decreased production of growth factors and chemokines [6], reduced angiogenesis [7], decreased proliferation and reduced migration of fibroblasts [8,9], and an impaired inflammatory response [10].”
• PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing (2008, background): “Recently, it has been shown in diabetic mouse (db/db) wound model that decreased level of SDF1a prevents circulating bone marrow progenitor cell migration into the wound site.(271,272)”
• Challenges in the Treatment of Chronic Wounds (2015, methodology): “Development of diagnostic tools, including biomarker analysis and noninvasive imaging, is necessary to better distinguish viable from nonviable tissues in the wound and guide debridement practices.(88) The importance of offloading the chronic wound cannot be overemphasized.”
• Chronic Wound Healing: A Review of Current Management and Treatments (2017, background): “A wide variety of factors is thought to contribute to this problem, affecting all phases of wound healing and seemingly nearly every molecule involved in this process [18], and evidence is emerging that proper glycemic control can have a significant impact on the rate of wound healing in a diabetic ”
• Therapeutic Strategies for Enhancing Angiogenesis in Wound Healing (2018, background): “Reduced angiogenesis plays a prominent role in the non-healing nature of diabetic foot ulcers and other chronic wounds [45].”
• Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights (2014, background): “Moreover, fibroblasts in diabetic wounds have been found to exhibit decreased proliferation, increased apoptosis and decreased migration ability [13, 21].”