Activity-dependent neuronal signalling and autism spectrum disorder

By D. H. Ebert, Michael E. Greenberg. Nature, 2013

610 citations recorded by the source corpus.

Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b5d58a7e07396af2759ded3b7aa9c1529ecfc9e5

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Citations in the corpus

Integrative functional genomic analysis of human brain development and neuropsychiatric risks (2018, background): “Putative promoters and enhancers (H3K27ac peaks) specific for DFC or CBC in the fetal, infant, or adult were enriched for SNP heritability identified through partitioned LD score regression analysis from GWASs for autism spectrum disorder [ASD, (40)], attention-deficit hyperactive disorder [ADHD, (4”
Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution. (2019, background): “Similar to longer exons, individual neuronal microexons can also affect orthogonal regulatory layers; for example, they alter the function of the lysine-specific histone demethylase 1A (KDM1A, also known as Lsd1), control activation domains of Mef2 family transcription factors, and regulate the acti”
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015, background): “Additionally, neuronal gene expression and epigenetic programmes also undergo changes at finer spatial and temporal scales, including changes induced by activity-dependent transcription in the nucleus and translation 209 at the synapse.”
Precise minds in uncertain worlds: predictive coding in autism. (2014, background): “Indeed, several of the genetic mutations linked to ASD have an important role in the regulation of plasticity (e.g., Delorme et al., 2013; Ebert & Greenberg, 2013; Hutsler & Zhang, 2010).”