A second class of chemosensory receptors in the olfactory epithelium

By S. Liberles, L. Buck. Nature, 2006

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Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota (2016, background): “a specific receptor or whether it acts to alter signaling pathways indirectly by altering the protein conformation (that is, via allosteric effects), whereas TMA has been reported to influence signal transduction by direct interaction with a family of G proteincoupled receptors (47).”
The Olfactory System (2014, background): “expressed in a subset of olfactory sensory neurons in the olfactory epithelium (Liberles and Buck 2006) (Fig.”
The G protein-coupled receptor subset of the rat genome (2007, background): “Moreover, it has recently been shown that the TAARs may act as chemosensory receptors in the olfactory epithelium [49,50].”
Anatomical profiling of G protein-coupled receptor expression (2008, neutral): “For example, neither our qPCR data (Supplemental Data Set) nor those of others (Liberles and Buck, 2006) detected trace amine associated receptor 1 (Taar1) expression in brain, but a Taar 1 Lac-Z knockin mouse revealed Taar1 expression in discrete neuronal populations and Taar1-dependent regulation ”