Mitogen-activated protein kinases in innate immunity

By J. Arthur, S. Ley. Nature reviews. Immunology, 2013

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Compromised MAPK signaling in human diseases: an update (2015, neutral): “Mitogen-activated protein kinases (MAPKs) are serine– threonine protein kinases that regulate various cellular activities including proliferation, differentiation, apoptosis, survival, inflammation, and innate immunity (Arthur and Ley 2013; Peti and Page 2013; Turjanski et al. 2007).”
TNF and MAP kinase signaling pathways (2014, neutral): “The mechanisms that account for TNFα regulation of the TPL2-MKK1/2-ERK1/2 [10] pathway remains unclear, but detailed studies of this pathway in the response to the endotoxin lipopolysaccharide (LPS) have been reported [10, 11].”
The MAPK pathway across different malignancies: A new perspective (2014, background): “In immune cells, activated ERK is also a component of the innate response in different steps of the inflammatory cascade, increasing the expression of tumor necrosis factor alpha (TNF-a) and inducible nitric oxide synthase (iNOS).(23) In addition to spatial activation, the final effect of the MAPK/E”