Tumour `budding' as an index to estimate the potential of aggressiveness in rectal cancer

By H. Ueno, J. Murphy, J. Jass, H. Mochizuki, I. Talbot. Histopathology, 2002

656 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “in the invasive front of several tumours and their presence has been shown to have prognostic significance in rectal and breast cancer [147,148] and has been associated with metastasis in colorectal cancer [149,150].”
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features (2007, background): “A diffuse growth pattern is also associated with a feature described as tumour budding or de-differentiation, in which there is a transition from glandular structures to single cells or clusters of up to four cells at the invasive margin (Figure 3e).(151) Tumour budding may and should be distinguish”
Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer (2014, background): “Tumour buds were defined as containing 1–5 cells only [13,34]; therefore Marker 1 objects must contain 1–5 associated nuclei to be classified as a tumour bud.”