Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease.

By Roshan Cools. Neuroscience and Biobehavioral Reviews, 2006

934 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/b4da6265ffa782b1a683de4b41e218b2e43f427d

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In Cellular and Molecular Neuroscience

In Neurology

Citations in the corpus

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, background): “Pro-dopamanergic drugs, including levo-dopa and pramipexole (a D2-like DA receptor agonist), have been associated with altering reversal learning to unexpected punishment and ICDs in patients with Parkinson’s disease (Cools, 2006; Cools et al, 2006).”
Metabolic brain networks associated with cognitive function in Parkinson's disease (2007, background): “The direct dopaminergic connections between the ventral tegmental area and the prefrontal cortex may also influence changes in cognition in this disease (e.g., Mattay et al., 2002; cf., Cools, 2006 for review).”
Prospective Optimization (2014, background): “When some PD patients are given dopaminergic therapy, they develop pathological gambling or other impulse control disorders [53], presumably due to ‘‘overdosing’’ dopamine levels in a relatively intact ventral striatum [54].”
Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. (2006, background): “Patients with Parkinson’s disease (PD), who have low levels of DA in the BG, are impaired at making choices that require learning from trial and error (Cools, 2005; Knowlton, Mangels, & Squire, 1996; Shohamy et al., 2004).”
Dopaminergic reward system: a short integrative review (2010, background): “These results might explain why L-DOPA treated PD patients become sometimes addicted to gambling [ 39 ,74].”
FROM REINFORCEMENT LEARNING MODELS OF THE BASAL GANGLIA TO THE PATHOPHYSIOLOGY OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS (2011, background): “Neurology typically deals with disorders with better understood etiology (for example, loss of dopaminergic neurons in Parkinson's disease), but even then it is often unclear how these etiological processes produce complex patterns of symptoms and why treatments can alleviate some deficits while exa”
Motor control and aging: links to age-related brain structural, functional, and biochemical effects. (2010, positive): “As described by the 'inverted-U' relationship between the level of dopamine and performance level, too much dopamine is as bad for performance as too little (for review see Cools, 2006).”
Hold your horses: A dynamic computational role for the subthalamic nucleus in decision making (2006, positive): “, 2000), it actually impairs performance in probabilistic reversal learning (Cools, 2005; Cools et al., 2001a; Swainson et al., 2000), that is when having to make decisions that require learning to overriding previously adaptive responses in favor of those that were less adaptive.”