Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre.

By J. Toledo, S. Arnold, Kevin M. Raible, J. Brettschneider, S. Xie, Murray C. Grossman, Sarah E. Monsell, W. Kukull, John Q. Trojanowski. Brain : a journal of neurology, 2013

774 citations recorded by the source corpus.

Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease, but the evidence for their association with other neurodegenerative disorders is limited. Therefore, we compared the prevalence of cerebrovascular disease, vascular pathology and vascular risk factors in a wide range of neurodegenerative diseases and correlate them with dementia severity. Presence of cerebrovascular disease, vascular pathology and vascular risk factors was studied in 5715 cases of the National Alzheimer's Coordinating Centre database with a single neurodegenerative disease diagnosis (Alzheimer's disease, frontotemporal lobar degeneration due to tau, and TAR DNA-binding protein 43 immunoreactive deposits, α-synucleinopathies, hippocampal sclerosis and prion disease) based on a neuropathological examination with or without cerebrovascular disease, defined neuropathologically. In addition, 210 'unremarkable brain' cases without cognitive impairment, and 280 cases with pure cerebrovascular disease were included for comparison. Cases with cerebrovascular disease were older than those without cerebrovascular disease in all the groups except for those with hippocampal sclerosis. After controlling for age and gender as fixed effects and centre as a random effect, we observed that α-synucleinopathies, frontotemporal lobar degeneration due to tau and TAR DNA-binding protein 43, and prion disease showed a lower prevalence of coincident cerebrovascular disease than patients with Alzheimer's disease, and this was more significant in younger subjects. When cerebrovascular disease was also present, patients with Alzheimer's disease and patients with α-synucleinopathy showed relatively lower burdens of their respective lesions than those without cerebrovascular disease in the context of comparable severity of dementia at time of death. Concurrent cerebrovascular disease is a common neuropathological finding in aged subjects with dementia, is more common in Alzheimer's disease than in other neurodegenerative disorders, especially in younger subjects, and lowers the threshold for dementia due to Alzheimer's disease and α-synucleinopathies, which suggests that these disorders should be targeted by treatments for cerebrovascular disease.

Subfields: Geriatrics and Gerontology, Neurology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/b470677950c6c00bd6d262c34418a6589c2f44b1

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In Neurology

1. C. Iadecola
2. J. Attems
3. J. Anrather
4. K. Jellinger
5. Berislav Zlokovic

In Psychiatry and Mental health

1. J. Attems
2. J. Anrather
3. C. Iadecola
4. K. Jellinger

Citations in the corpus

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• Religious Orders Study and Rush Memory and Aging Project (2018, neutral): “pathologic studies are recruited at tertiary care dementia centers [3, 4].”
• Impact of Hypertension on Cognitive Function (2016, neutral): “Conversely, individuals with hypertension are also more likely to be categorized as having vascular or mixed dementia rather than “pure” AD, and this diagnostic bias could result in an apparent protective effect of hypertension on clinically diagnosed AD.”
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• Vascular dysfunction – the disregarded partner of Alzheimer’s disease (2019, neutral): “[5] Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, et al.”
• The pathobiology of vascular dementia (2013, neutral): “…the role of cerebrovascular disease, not only as a primary cause of cognitive impairment, but also as an adjuvant to the expression of dementia caused by other factors, including AD and other neurodegenerative pathologies (Gorelick et al., 2011; Schneider et al., 2007a; Toledo et al., 2013).”
• Role of neuroinflammation in neurodegeneration development (2023, background): “9% of AD patients.(134) Recently, an important study published by Yang et al.”