Applications of Alginate-Based Bioinks in 3D Bioprinting
By E. Axpe, M. Oyen. International Journal of Molecular Sciences, 2016
566 citations recorded by the source corpus.
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioink formulation, a critical component of efficient 3D bioprinting. Alginate, a naturally occurring polysaccharide, is clearly the most commonly employed material in current bioinks. Here, we discuss the benefits and disadvantages of the use of alginate in 3D bioprinting by summarizing the most recent studies that used alginate for printing vascular tissue, bone and cartilage. In addition, other breakthroughs in the use of alginate in bioprinting are discussed, including strategies to improve its structural and degradation characteristics. In this review, we organize the available literature in order to inspire and accelerate novel alginate-based bioink formulations with enhanced properties for future applications in basic research, drug screening and regenerative medicine.
Subfields: Biomedical Engineering, Biophysics
View Paper: https://www.semanticscholar.org/paper/079fda9bc4b5a722759f0665da1878ead7093e6c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biomedical Engineering
In Biophysics
Citations in the corpus
- Recent trends in bioinks for 3D printing (2018, background): “This characteristic property is ideal for 3D bioprinting bioinks [43, 44].”
- Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “…and rapid degradation of the alginate hydrogel somewhat limits its application for 3D cultures but alginate hydrogels have found their use as 3D-printed scaffolds for specialized tissue such as vascular tissue, bone and cartilage (Axpe and Oyen, 2016; Joddar et al., 2016; Silva et al., 2017).”