Role of deficient type III interferon-lambda production in asthma exacerbations.

By M. Contoli, S. Message, V. Laza-Stanca, M. Edwards, P. Wark, N. Bartlett, T. Kebadze, P. Mallia, L. Stanciu, Hayley L. Parker and 8 more. Nature Medicine, 2006

609 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b3af43e2a1f5593d490917d989c89ef2c06b350f

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1. P. Barnes
2. C. Sommereyns
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4. S. Paul
5. E. Kieninger
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8. M. Edwards

Citations in the corpus

• IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo (2008, background): “The effect of IFN-l against vaginal infection by HSV-2 [17], the inverse correlation between rhinovirus-induced IFN-l expression and viral load in infected volunteers [53], and the antagonistic activity of Yaba-like virus against IFN-l [11], support an active role for this IFN.”
• The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “sion in epithelial cells of asthmatic patients and are associated with increased rhinovirus replication, which may predispose these patients to viral exacerbations of asthma (28, 29).”
• The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, background): “The importance of IFN responses to respiratory viruses by the airway epithelium is underscored by studies of asthmatics which suggest that these patients have a deficient IFN- and IFN- response to rhinovirus infection (35, 310).”