Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease

By N. Villanova, S. Moscatiello, S. Ramilli, E. Bugianesi, D. Magalotti, E. Vanni, M. Zoli, Giulio Marchesini. Hepatology, 2005

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Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013, positive): “This decrease is correlated to histological features of NAFLD independent of age, sex, BMI, HOMA-insulin resistance, and other metabolic syndrome (MS) components [20,79].”
INCREASED HEPATIC SYNTHESIS AND DYSREGULATION OF CHOLESTEROL METABOLISM IS ASSOCIATED WITH THE SEVERITY OF NONALCOHOLIC FATTY LIVER DISEASE (2012, background): “Several studies have also linked NAFLD to an increased risk of cardiovascular disease, a leading cause of death in this population (Brea et al., 2005; Hanley C et al., 2005; Targher et al., 2007; Villanova et al., 2005).”
A position statement on NAFLD/NASH based on the EASL 2009 special conference. (2010, background): “Interestingly, endothelial dysfunction, an early proatherogenic lesion is also associated with NAFLD, and is more advanced in NASH than in bland steatosis [99].”