βKlotho is required for metabolic activity of fibroblast growth factor 21

By Y. Ogawa, H. Kurosu, Masaya Yamamoto, A. Nandi, K. Rosenblatt, R. Goetz, A. V. Eliseenkova, M. Mohammadi, M. Kuro-o. Proceedings of the National Academy of Sciences of the United States of America, 2007

612 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b352259d3840e82851b3b20c48789a93afe782a5

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In Molecular Biology

1. M. Kuro-o
2. M. Mohammadi
3. D. Moller
4. D. Mangelsdorf

Citations in the corpus

• Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010, background): “-Klotho is known to form complexes with FGFR1c and FGFR3c that interact efficiently with FGF21 (19, 20, 81).”
• Fibroblast growth factor 21 corrects obesity in mice. (2008, background): “We focused this line of research on liver, fat, and pancreas, which represent primary target tissues for FGF21 action because they express Klotho (8) and various FGF receptors (9), the required components of FGF21 receptor machinery (10–12), and respond to FGF21 stimulation in a direct way (2, 3, 5,”
• Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans (2008, background): “The metabolic effects of FGF21 in adipocytes were mediated by beta-Klotho, a single-pass transmembrane protein whose expression is induced during adipogenesis (15).”
• Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice (2009, background): “-klotho binds FGF21 and facilitates its activation of FGFRs (11,12).”