Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

By B. Yipp, B. Petri, D. Salina, C. Jenne, Brittney N. V. Scott, L. Zbytnuik, K. Pittman, M. Asaduzzaman, Kaiyu Wu, H. C. Meijndert and 5 more. Nature Medicine, 2012

965 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/b2d11d3a11ae4eb6770fa2938db99837174a3b30

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. C. Rosales
2. P. Kubes

In Immunology

1. P. Kubes
2. C. Rosales
3. K. Martinod
4. D. Wagner
5. C. Lowell
6. B. Yipp
7. T. Mayadas
8. X. Cullere

In Pulmonary and Respiratory Medicine

1. P. Kubes

Citations in the corpus

• Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “NETosis, the process for producing NETs can be activated by multiple types of microorganisms (Fuchs et al., 2007; Yipp et al., 2012).”
• The Multifaceted Functions of Neutrophils (2013, background): “Although the expulsion of DNA to form NETs may be considered an end point for neutrophils, recent work suggests that anuclear neutrophils can migrate and retain the necessary components to kill bacteria through conventional mechanisms (128).”
• A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis (2014, neutral): “A fraction of neutrophils have also been reported to release NETs without dying, leaving behind cytoplasts that continue to ingest microbes (Pilsczek et al., 2010; Yipp et al., 2012).”
• Inflammation and aging: signaling pathways and intervention therapies (2023, background): “NETs in staphylococcal skin infections inhibit the penetration of pathogens into the bloodstream.(268) Knockout of the PAD4 gene in mice prevents NET formation and leads to more severe necrotizing fasciitis caused by streptococcus pyogenes.”
• Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “A recent study using this technology showed that phagocytosis and NETosis act in concert to combat Staphylococcus aureus in vivo, supporting a novel “neutrophil multitasking” concept in host–pathogen interactions [44].”
• NETosis: how vital is it? (2013, background): “Here we describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic NETosis and a live cell or vital NETosis.”
• Thrombosis: tangled up in NETs. (2014, background): “80 In TTP characterized by low ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type- 1 motifs 13), NET biomarkers are elevated during acute TTP compared with the same patients in remission (Figure 4C), 80 making it a possibility that the disease could be precipitated by an inf”