Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

By Takahiro Masuda, R. Sankowski, O. Staszewski, C. Böttcher, Lukas Amann, Sagar, Christian Scheiwe, S. Nessler, Patrik Kunz, G. van Loo and 9 more. Nature, 2019

1,081 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/b27ad5fa7c0907c87c20b89c717037860861f4ce

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Citations in the corpus

Complex heatmap visualization (2022, positive): “ComplexHeatmap has been applied to build comprehensive visualization in a wide range of biology studies, such as on cancers [15], COVID ‐ 19 [16], single cells [17], immunology [18], as well as in other fields, such as oceanology [19] and ecology [20].”
The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “Single-cell sequencing has identified many subsets of immune cells with distinct roles in neuroinflammation that likely interact with the BBB in disease (Mrdjen et al., 2018; Jordão et al., 2019; Kierdorf et al., 2019; Masuda et al., 2019; Mundt et al., 2019).”
Overview of General and Discriminating Markers of Differential Microglia Phenotypes (2020, background): “…viral infections, stroke, paraneoplastic disorders, and traumatic brain injury (Lehnardt et al., 2003; Marshall et al., 2013; Walker and Lue, 2015; Mathys et al., 2017; Lowry and Klegeris, 2018), but precise mechanisms remain to be elucidated (Amor et al., 2010; Chitnis and Weiner, 2017).”
ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020, background): “The physiological and transcriptional heterogeneity of microglia throughout life, differences in brain regions and disease have become apparent [81,82] and it may be possible that NOX1 is expressed in different stages of development, in ageing or certain pathological settings.”
Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues (2023, neutral): “Under steady-state conditions, these resident macrophage-like cells of the brain display little heterogeneity between different brain regions and have a mostly rami ﬁ ed phenotype 26,27 .”
Microglia states and nomenclature: A field at its crossroads (2022, positive): “68,69,91 Relatively small transcriptional differences may, however, lead to relevant functional differences, as exempliﬁed by the functional variations between hippocampal and cerebellar microglia.”