Regulation of type I interferon responses

By L. Ivashkiv, L. Donlin. Nature reviews. Immunology, 2013

3,093 citations recorded by the source corpus.

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs). Host, pathogen and environmental factors regulate the responses of cells to this signalling pathway and thus calibrate host defences while limiting tissue damage and preventing autoimmunity. Here, we summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation. These regulatory mechanisms determine the biological outcomes of type I IFN responses and whether pathogens are cleared effectively or chronic infection or autoimmune disease ensues.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/b23ce2547e6ec2138baefe4bc3d530323901a9c4

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Citations in the corpus

Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells (2015, neutral): “Type-I IFN is produced by many cell types, including dendritic cells (DCs) (Ivashkiv and Donlin, 2014; Stetson and Medzhitov, 2006).”
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression (2017, neutral): “pSTAT1, pSTAT3, and IRF9 induction was also observed through interferon alpha and beta, consistent with the canonical type I interferon signaling pathway (Ivashkiv and Donlin, 2014).”
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor (2016, neutral): “IFNAR1 activation triggers JAK1/TYK2-dependent phosphorylation of STAT1, which dimerizes with phosphorylated STAT2 17 .”
Coronavirus infections and immune responses (2020, background): “Thus, blocking the production of IFNs has a direct effect on the survival of the virus in the host.(39,40) So far, PRRs are”
Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses (2015, neutral): “This activation could induce tumor attraction of lymphocytes (Ivashkiv and Donlin, 2014).”
Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19 (2020, background): “Type I and type III IFNs establish the cellular state of viral resistance, as well as activate the adaptive immune responses to viruses (Ivashkiv and Donlin, 2014).”
Parsing the interferon transcriptional network and its disease associations (2016, neutral): “…besides this canonical conduit, IFN also activates several other signaling pathways: other STAT family members such as STAT3, especially in the absence of STAT1; the MAPK cascades (p38 and ERK); PI-3K and the mTOR-Akt-S6K axis (reviewed in (Uddin and Platanias, 2004; Ivashkiv and Donlin, 2014)).”