Participation of patients 65 years of age or older in cancer clinical trials.
By Joy H Lewis, M. Kilgore, D. Goldman, E. Trimble, R. Kaplan, M. Montello, M. Housman, J. Escarce. Journal of Clinical Oncology, 2003
1,026 citations recorded by the source corpus.
Subfields: Cancer Research, Geriatrics and Gerontology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/b1e030391c15c534963bfb4d91b5948b6e38265a
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In Cancer Research
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Citations in the corpus
- Randomised controlled trials and population-based observational research: partners in the evolution of medical evidence (2014, background): “Patients with advanced age and greater comorbidity (Hutchins et al, 1999; Lewis et al, 2003), and those from lower socioeconomic background (Unger et al, 2013) are under-represented in RCTs.”
- Annual Report to the Nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden (2002, background): “One of the obstacles to clinical trial access for the older patient may be the organ function eligibility requirements.(64) In addition, the ACS provides numerous services to cancer patients and their families.”
- An electronic application for rapidly calculating Charlson comorbidity score (2004, background): “It also limits the applicability of clinical research to large segments of the oncology population because protocol designs tend to exclude older and sicker patients [21,22].”
- The impact of comorbidity on cancer and its treatment (2016, background): “The interpretation of these findings is complicated by the finding that most cancer clinical trials exclude patients with substantial comorbidity, which makes the assessment of both toxicity and treatment effectiveness among these patients difficult.(114) Comparing the cancer outcomes of cancer pati”
- Participation in cancer clinical trials: race-, sex-, and age-based disparities. (2004, background): “Race-related variability in stage of diagnosis and stringent trial exclusion criteria may also contribute to disparities in trial eligibility and participation.(11,27) Applying trial results to patients who would not have been eligible to participate has been associated with harm.”