Overexpression of the enzyme p-hydroxyphenolpyruvate dioxygenase in Arabidopsis and its relation to tocopherol biosynthesis

By Yoseph Tsegaye, David K Shintani, D. DellaPenna. 2002

130 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b0dfafca05ce41d126f9b405526e04fd8cae9195

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Pogson
2. D. Gupta
3. J. Palma
4. D. DellaPenna
5. F. J. Corpas

In Molecular Biology

1. B. Pogson
2. N. Dudareva
3. D. Gupta
4. J. Palma
5. Hiroshi A. Maeda
6. D. DellaPenna
7. F. J. Corpas

Citations in the corpus

• Vitamin synthesis in plants: tocopherols and carotenoids. (2006, background): “To test this hypothesis HPPD was overexpressed in Arabidopsis seed and leaves (137) resulting in more than a 20-fold increase in activity but only a 15% and 30% increase in seed and leaf tocopherols, respectively.”
• Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “So far, studies in Arabidopsis reported an increase in leaf tocopherol of 1.4- and 4.4-fold by overexpression of HPPD or HPT1, respectively (Tsegaye et al. 2002; Collakova and DellaPenna 2003a).”
• The shikimate pathway and aromatic amino Acid biosynthesis in plants. (2012, background): “Because an overexpression of Arabidopsis 4-hydroxyphenylpyruvate dioxygenase alone had only a limited effect on tocopherol production (48, 189), both supply of 4-hydroxyphenylpyruvate and its subsequent conversion to homogentisate represent bottlenecks in vitamin E accumulation in plants.”
• Characterization of an Arabidopsis mutant deficient in γ-tocopherol methyltransferase (2003, background): “…that γ -TMT is not a limiting factor for overall tocopherol synthesis, but that other genes, viz. p-hydroxyphenolpyruvate dioxygenase and homogentisate phytyltransferase, control carbon flux into tocopherol synthesis (Shintani and DellaPenna, 1998; Tsegaye et al., 2002; Collakova et al., 2003).”
• Vitamin E Is Essential for Seed Longevity and for Preventing Lipid Peroxidation during Germination (2004, unknown): “…cloned pathway enzymes have been used in various transgenic approaches to successfully modify the amount and types of tocopherols that accumulate in leaves and seeds (Shintani and DellaPenna, 1998; Savidge et al., 2002; Tsegaye et al., 2002; Cahoon et al., 2003; Collakova and DellaPenna, 2003a).”