Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

By R. Pai, B. Soreghan, I. Szabó, M. Pavelka, D. Baatar, A. Tarnawski. Nature Medicine, 2002

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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (2009, background): “Indeed, PGE2 has been reported to activate pro-survival pathways including the PI3K/AKT pathway [67,68], ERK signalling [69], cAMP/PKA signalling [70], and activation of epidermal growth factor receptor (EGFR) signalling [71,72].”
Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. (2004, background): “Recently, a novel EP2 receptor signaling pathway has been described in which PGE2 simulation leads to transactivation of the EGF receptor leading to increased migration and invasion of colon cancer cells (Pai et al., 2002; Buchanan et al., 2003).”
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (2003, background): “PGE2 is mitogenic for gastric epithelial cells and a number of colon cancer cell lines (Pai et al. 2002).”