Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

By J. Barrett, S. Hansoul, Dan L. Nicolae, Judy H. Cho, R. Duerr, J. Rioux, S. Brant, M. Silverberg, K. Taylor, M. Barmada and 51 more. Nature Genetics, 2008

2,710 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/b0bdf3ae1977779a0bb1b0256819fc18c9a67f64

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In Genetics

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Citations in the corpus

• Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci (2009, background): “, as is the PTGER4 MS allele and the known Crohn's disease allel”
• Unravelling the effects of the environment and host genotype on the gut microbiome (2011, background): “Genes that are implicated in innate or adaptive immunity have been shown in GWA studies to be associated with inflammatory disease”
• Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). (2009, background): “This is of especial note, given the aforementioned observations on IL-23 production by HLAB27 transgenic rat macrophages, the already established role for IL-23R in susceptibility to CD (164) and psoriasis (210), and the emerging role for IL-23 in the differentiation of the Th17 subset of T lymphocy”
• A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies (2009, methodology): “…because of improved catalogues of human genetic variation [4] and advances in genotyping technology, but it has also been bolstered by the rise of genotype imputation methods [5–8], which have allowed researchers to tease increasingly subtle signals out of large and complex genetic datasets [9,10].”
• Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions (2009, background): “First, in Crohn’s disease, we start with a long list of putative SNP associations from a recent GWA (genome-wide association) meta-analysis [ 24 ].”
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010, result): “When combined with recent reports of additional T2D susceptibility loci arising from studies of continuous glycemic traits 12 , 13 and parent-of-origin effects 11 , the number of confirmed loci for T2D currently stands at 38 .”
• Uncovering the roles of rare variants in common disease through whole-genome sequencing (2010, background): “The general failure of GWA studies of very common variants to identify causal sites has led to the widespread belief that most signals must reflect subtle regulatory variants that are not easily recognize”