The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin.
By Jeffrey B. Woodruff, Beatriz Ferreira Gomes, P. Widlund, J. Mahamid, A. Honigmann, Anthony A. Hyman. Cell, 2017
607 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b0ac005939e832919b420ea74c38ff840ed70474
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Citations in the corpus
- Liquid-Liquid Phase Separation in Disease. (2019, methodology): “Examples of membraneless compartments are the nucleolus (50, 107) in the nucleus or centrosomes (155) in the cytoplasm of cells.”
- Liquid phase condensation in cell physiology and disease (2017, background): “Reaction-controlled assembly also appears to play a role in the centrosome, where cycles of reactivity associated with localized kinase activity drive centrosomal proteins to condense around a single centriole, preventing the formation of multiple centrosomes that could promote mitotic defects (121,”
- A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins (2018, unknown): “, 2016; Protter and Parker, 2016), or coiled-coil proteins (Woodruff et al., 2017).”
- OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization (2022, background): “…compartmentsforwhichbiomolecularconden-sationhasbeenproposedtoplayanimportant role(Fig.5G),namelyP-bodies( 64 ), stress granules ( 59 ), centrosome ( 65 ), cell junctions ( 66 ), and the interface between cell surface and actin cytoskeleton ( 67 ).”