Getting up to speed with transcription elongation by RNA polymerase II
By I. Jonkers, J. Lis. Nature reviews. Molecular cell biology, 2015
830 citations recorded by the source corpus.
Recent advances in sequencing techniques that measure nascent transcripts and that reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in promoter-proximal regions and its release to initiate a phase of productive elongation are key steps in transcription regulation. Moreover, after the release of Pol II from the promoter-proximal region, elongation rates are highly dynamic throughout the transcription of a gene, and vary on a gene-by-gene basis. Interestingly, Pol II elongation rates affect co-transcriptional processes such as splicing, termination and genome stability. Increasing numbers of factors and regulatory mechanisms have been associated with the steps of transcription elongation by Pol II, revealing that elongation is a highly complex process. Elongation is thus now recognized as a key phase in the regulation of transcription by Pol II.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b04a80bb634b7679b7f82d36069c5b6414f4effd
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Citations in the corpus
- BRD4 and Cancer: going beyond transcriptional regulation (2018, background): “RNA-PolII pausing at promoter-proximal regions and its release into active transcription are a major rate limiting steps of gene expression [25].”
- Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III (2020, background): “RNA polymerases synthesize RNA, forming DNA, RNA, and protein ternary complexes in the nucleus [27-29].”
- Cohesin loss eliminates all loop domains (2017, methodology): “Similarly, RNA polymerase II can push cohesin along DNA (Davidson et al., 2016) but elongation rate estimates (9–90 bp/s; (Jonkers and Lis, 2015)) are slower than what we observe.”