Personal genomes: The case of the missing heritability

By B. Maher. Nature, 2008

1,734 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/afcc8497b911811d7df66878418870a3fc648ee9

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In Genetics

Citations in the corpus

Epigenetics as a unifying principle in the aetiology of complex traits and diseases (2010, background): “An informative example is height: height is 80–90p heritable, but the 40 loci that have been detected in genome-wide association studies together account for less than 5p of heritability for heigh”
A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis (2010, background): “Since loci with weaker associations may contribute to a portion of the so-called ‘ missing ’ or ‘ dark ’ heritability [5-7], multiple locus analyses have the potential to provide a more complete picture of heritable variation.”
Beyond DNA: integrating inclusive inheritance into an extended theory of evolution (2011, result): “This became strikingly obvious when genome-wide association studies (GWA studies) showed that most of the high heritabilities for phenotypic traits, such as height or common human diseases, could not be explained by common genetic variant”
Rare Variants Create Synthetic Genome-Wide Associations (2010, result): “On balance, therefore, our results suggest that even though the apparent impact of common variants is only modest for many traits [6,22,23], this impact may have been systematically overestimated [24].”
Common disorders are quantitative traits (2009, background): “We do not address the GWA debates about common versus rare variants or about 'missing heritability”
Estimating Effects and Making Predictions from Genome-Wide Marker Data (2010, background): “This is disappointing and typical of other traits, leading to the question “Where are the missing genes?” [34].”
Common SNPs explain a large proportion of heritability for human height (2010, background): “Where is the missing heritability, the so-called dark matter of the genom”
Genetic foundations of human intelligence (2009, background): “Intelligence is not unusual in the difficulties it has found in trying to identify the genes responsible for its high heritability (Maher 2008).”
Genetics of bipolar disorder. (2011, background): “Still, the current findings might shed some light on the biology of BPD [see (Maher 2008) for a general review on small effect sizes and GWAS].”
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes (2009, background): “is correct, additional genetic susceptibility loci remain to be identified, which is also true for many other diseases in which loci have been successfully mapped by GW”