Complement C3 variant and the risk of age-related macular degeneration.

By J. Yates, T. Sepp, Baljinder K. Matharu, J. Khan, D. Thurlby, Humma Shahid, David Clayton, C. Hayward, J. Morgan, A. Wright and 6 more. New England Journal of Medicine, 2007

832 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Ophthalmology

View Paper: https://www.semanticscholar.org/paper/af55a840fb0c6e4004c4acfff588c5a7862251bd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. John P. A. Ioannidis

In Molecular Biology

1. Gonçalo R. Abecasis
2. Evangelos Evangelou
3. Mark J. Daly
4. Yusuke Nakamura
5. John P. A. Ioannidis
6. Emily Y. Chew
7. Eric Boerwinkle
8. David Clayton

In Ophthalmology

1. Emily Y. Chew
2. Baljean Dhillon
3. G. Hageman

Citations in the corpus

• Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait (2010, neutral): “In most cases, the causal variant or variants have not been identified, although there are some strong candidate”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “…in other complement pathway genes that influence the risk for AMD were identified such as C3 (rs2230199), factor I (rs10033900), and the C2/factor B locus (rs9332739, rs547154, rs4151667, and rs641153) (Fagerness et al., 2009; Gold et al., 2006; Spencer et al., 2007; Yates et al., 2007).”
• Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout (2009, methodology): “Population attributable risk (PAR) was calculated using the formula PAR (%) [ (pi)(RRi-1)/[1 (pi)(RRi 1)]] 100, where pi corresponds to the proportion of individuals exposed to the risk allele (separate groups for heterozygotes and risk homozygotes) among those without gout, and RRi is estimated by ”
• Seven New Loci Associated with Age-Related Macular Degeneration (2013, background): “[17,18], Gabriëlle H S Buitendijk [19,20], Xueling Sim [2,21], Daniel E Weeks [22,23], Robyn H Guymer [24], Joanna E Merriam [25], Peter J Francis [26], Gregory Hannum [27], Anita Agarwal [28,29], Ana Maria Armbrecht [30], Isabelle Audo [10,31,32,33], Tin Aung [34,35], Gaetano R Barile [25], Mustaph”
• The Pivotal Role of the Complement System in Aging and Age-related Macular Degeneration: Hypothesis Re-visited (2009, neutral): “Subsequently, two non-synonymous polymorphisms in the C3 gene were also reported to be associated with AMD (Despriet et al., 2009; Maller et al., 2007; Park et al., 2009a; Yates et al., 2007), a result that further reinforced the conclusion that the complement system e and the interactive CFH, CFB, ”