Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

By O. Woodward, A. Köttgen, Josef Coresh, Eric Boerwinkle, W. Guggino, M. Köttgen. Proceedings of the National Academy of Sciences of the United States of America, 2009

661 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Nephrology

View Paper: https://www.semanticscholar.org/paper/0a1700463f95540645475c8fa17860d2e72b4bdd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Ian J. Deary
2. Luigi Ferrucci

In Nephrology

1. Josef Coresh
2. A. Levey

Citations in the corpus

• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “A recent genome-wide association study identified a common single-nucleotide polymorphism in ABCG2 (BCRP) as a determinant of serum urate levels and gout (Woodward et al., 2009).”
• Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans (2015, background): “The ATP-binding cassette transporter ABCG2 has been established as a high capacity urate transporter, is expressed in renal proximal tubules, liver and intestines, and the hyperuricemia causal Q141K mutation has been shown to reduce urate transport rates [39].”
• ProbABEL package for genome-wide association analysis of imputed data (2010, methodology): “…of GWAS is confirmed by the fact that the early versions of the package were successfully used for analysis of multiple data sets, including already published genome-wide analyzes of such various traits as height [26,27], gout [28], waist circumference [29], smoking initiation [30], and others.”