Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
By Yi Xu, Xufang Li, B. Zhu, Huiying Liang, Chun-xiao Fang, Y. Gong, Qiaozhi Guo, Xin Sun, Danyang Zhao, Jun Shen and 6 more. Nature Medicine, 2020
1,380 citations recorded by the source corpus.
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal–oral transmission. Children infected with the COVID-19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission.
Subfields: Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/af139b990f8c885d668d7639f609b7ff6a6f9e5c
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In Infectious Diseases
Citations in the corpus
- Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization (2020, background): “Studies have detected SARS-CoV-2 virus in anal swabs and stool samples in almost 50% of patients with COVID-19, suggesting that the digestive tract might be an extrapulmonary site for virus replication and activity.(6,7) Moreover, fecal calprotectin was found to be elevated in patients with COVID-19”
- A Review of SARS-CoV-2 and the Ongoing Clinical Trials (2020, background): “[7] Indeed, it was reported that the rectal swabs showed positive results even after the nasopharyngeal tests were constitutively negative [8].”
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020, positive): “Persistent viral RNA in rectal swabs has been detected in pediatric infection, even after negative nasopharyngeal tests (Xu et al., 2020).”
- SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area (2020, background): “Even though the possibility of faecal-oral transmission has been hypothesized, the role of secretions in the spreading of the disease is not clarified yet (W. Wang et al., 2020b; Y. Wu et al., 2020b; Xu et al., 2020; Yeo et al., 2020).”