Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
By T. A. Clayton, Dave J. Baker, John C. Lindon, J. Everett, Jeremy K. Nicholson. Proceedings of the National Academy of Sciences of the United States of America, 2009
744 citations recorded by the source corpus.
Subfields: Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/af0637238fcd343d3dd2a1111604b6e6556aac26
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Rob Knight
- C. Lauber
- William Walters
- Dirk Gevers
- Laura Wegener Parfrey
- Eran Elinav
- José Carlos Clemente
- Martin J. Blaser
In Pharmacology
Citations in the corpus
- Experimental and analytical tools for studying the human microbiome (2011, background): “Investigations into the RNAs, proteins and metabolites that are present — processes that are referred to as metatranscriptomics, metaproteomics and metabolomics, respectively — can also provide valuable insights, especially when they are combined with community surveys and metagenomic dat”
- Supervised classification of human microbiota. (2011, neutral): “For example, gastrointestinal microorganisms are involved in xenobiotic metabolism (Clayton et al ., 2009), dietary polysaccharide degradation (Turnbaugh et al ., 2009a, b; Hehemann et al ., 2010), immune system development (Hooper, 2001), and a wide range of other functions.”
- Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. (2016, positive): “Additionally, the microbiota has been implicated in APAP metabolism (Clayton et al., 2009).”
- Microbiome and Malignancy (2011, background): “Finally, the microbiome affects the metabolism of xenobiotics (Figure 2), such as pharmaceutical agents (Clayton et al., 2009), including those used to treat cancer.”
- Gut microbiome-host interactions in health and disease (2011, background): “Moreover, the intestinal microbiome is essential for determining the toxic response to pharmacological therapies, and the case of paracetamol permits pre-dose predictions of toxicity to be made [18,59].”