In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

By D. Grimm, Joyce S. Lee, L. Wang, T. Desai, Bassel Akache, Theresa A. Storm, M. Kay. Journal of Virology, 2008

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Immune responses to AAV vectors: overcoming barriers to successful gene therapy. (2013, positive): “99%, but studies with naturally occurring serotypes 56 and purpose-engineered capsids 57-59 have shown that even small differences in capsid sequence may affect tissue tropism of a vector and can be exploited to improve therapeutic outcomes.”
State-of-the-art gene-based therapies: the road ahead (2011, background): “and by constructing large libraries of randomly shuffled capsid DNA that are placed under selective pressure for certain desired propertie”