Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.

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Design of Curcumin Loaded PLGA Nanoparticles Formulation with Enhanced Cellular Uptake, and Increased Bioactivity in vitro and Superior Bioavailability in vivo (2009, positive): “Extensive research within the last two decades has revealed that curcumin exhibits antioxidant, anti-inflammatory, anti-survival, antiproliferative, anti-invasive and antiangiogenic activity [5].”
The complexity of NF-κB signaling in inflammation and cancer (2013, background): “Nevertheless, combining classical chemotherapeutics with inhibitors of NF-κB activation seems to result in promising synergies (see [154-165] for some examples).”
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. (2008, neutral): “[9] Kunnumakkara AB, Anand P, Aggarwal BB.”
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases (2017, background): “…signalling pathways linked to different chronic diseases, which strongly suggest that it is a potent multi-targeted polyphenol (Anand et al., 2008; Kunnumakkara et al., 2008; Ravindran et al., 2009; Goel and Aggarwal, 2010; Hasima and Aggarwal, 2012; Aggarwal et al., 2015; Rainey et al., 2015).”