The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance
By P. Alonso-Magdalena, S. Morimoto, C. Ripoll, E. Fuentes, A. Nadal. Environmental Health Perspectives, 2005
641 citations recorded by the source corpus.
The function of the pancreatic β-cell is the storage and release of insulin, the main hormone involved in blood glucose homeostasis. The results in this article show that the widespread environmental contaminant bisphenol-A (BPA) imitates 17β-estradiol (E2) effects in vivo on blood glucose homeostasis through genomic and nongenomic pathways. The exposure of adult mice to a single low dose (10 μg/kg) of either E2 or BPA induces a rapid decrease in glycemia that correlates with a rise of plasma insulin. Longer exposures to E2 and BPA induce an increase in pancreatic β-cell insulin content in an estrogen-receptor–dependent manner. This effect is visible after 2 days of treatment and starting at doses as low as 10 μg/kg/day. After 4 days of treatment with either E2 or BPA, these mice developed chronic hyperinsulinemia, and their glucose and insulin tolerance tests were altered. These experiments unveil the link between environmental estrogens and insulin resistance. Therefore, either abnormal levels of endogenous estrogens or environmental estrogen exposure enhances the risk of developing type 2 diabetes mellitus, hypertension, and dyslipidemia.
Subfields: Genetics, Health, Toxicology and Mutagenesis, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/ae8c61fc130e5b1a2689f3203764105da51dc5ee
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Citations in the corpus
- Concentrations of Urinary Phthalate Metabolites Are Associated with Increased Waist Circumference and Insulin Resistance in Adult U.S. Males (2007, background): “Among xenoestrogens, bisphenol A (currently unmeasured in NHANES) would be important to investigate because it has recently been shown to affect insulin production in mouse pancreatic beta cells in a manner similar to that of estrogen (Alonso-Magdalena et al. 2006).”
- Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. (2008, background): “Four days of low-dose BPA injections also pro duced insulin resistance in mice.(41) Other studies have identified associa tions between environmental toxins, body weight, and diabetes,(42,43) and it has been proposed that exposure to some en vironmental pollutants may initiate or ex acerbate the”
- In vivo effects of bisphenol A in laboratory rodent studies. (2007, background): “[140] Alonso-Magdalena P, Morimoto S, Ripoll C, Fuentes E, Nadal A.”
- In vitro molecular mechanisms of bisphenol A action. (2007, background): “…Insulin release-RIA Krebs-Ringer bicarbonate buffer –16.7 mM glucose 60 min, 24 h nd, 4.4 × 10−8* 4.4 × 10−10, 4.4 × 10−9, 4.4 × 10−8*, 4.4 × 10−8*, 4.4 × 10−6 Actinomycin-D; ICI 182,780 E2; NP Alonso-Magdalena et al. 2005 [66] Mice Swiss albino OF1 Male; primary pancreatic islets and isolated…”
- Bisphenol A and human health: a review of the literature. (2013, background): “BPA increases BMI by causing insulin resistance [136], altering the adiponectin release from 19 adipose tissue [137], and increased inflammatory cytokines [138].”