Transient cyclical methylation of promoter DNA

By S. Kangaspeska, B. Stride, R. Métivier, M. Polycarpou-Schwarz, David Ibberson, Richard P. Carmouche, Vladimir Benes, F. Gannon, G. Reid. Nature, 2008

667 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ae3840ef225953be45e281741050fe382f336b6f

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In Molecular Biology

1. Yi Zhang
2. K. Hochedlinger
3. F. Lubin
4. T. Roth
5. Kathrin Plath
6. Susan C. Wu
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8. J. Sweatt

Citations in the corpus

• Rapid DNA methylation changes after exposure to traffic particles. (2009, background): “A previous study of 30 healthy volunteers reported cyclic variations in blood DNA methylation content observed over a 24hour period (36), and recent investigations have shown transient cyclical methylation and demethylation of specific gene promoters (37, 38).”
• Active DNA demethylation: many roads lead to Rome (2010, background): “For example, the pS2 (also known as TFF1 ) promoter exhibits periodic methylation and demethylation that coincides with cyclical binding of oestrogen receptor-α ( ERα ) and expression of pS2 (Ref”
• Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “Remarkably, there is a rapid cycling of DNA methylation and demethylation at the promoters of PS2 and other oestradiol-estrogen receptor target genes, with a periodicity of approximately 100 min (50, 66).”
• Epigenetic reprogramming and induced pluripotency (2009, background): “However, the nature and existence of demethylating enzymes in mammals remains highly controversial (Barreto et al., 2007; Bhattacharya et al., 1999; Hendrich et al., 2001; Jin et al., 2008; Kangaspeska et al., 2008; Metivier et al., 2008).”
• Acute exercise remodels promoter methylation in human skeletal muscle. (2012, background): “DNA methyl transferases 3A and 3B (DNMT3A and DNMT3B, also called de novo methyl transferases) possess demethylase activity, but the biochemical sequence is unknown (Kangaspeska et al., 2008; Métivier et al., 2008).”
• Epigenetic inheritance during the cell cycle (2009, background): “Although we have learnt about the maintenance mechanisms that ensure the stable propagation of marks, it will also be important to consider mechanisms that enable the removal of these marks to fully comprehend the dynamic behaviour of DNA methylation, as suggested by recent report”
• DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 (2008, positive): “, 2000; Reik, 2007), and recent evidence for cyclical DNA demethylation at ERa targets (Kangaspeska et al., 2008; Metivier et al., 2008).”
• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “Alternatively, DNMTs have recently been discovered to be regulators of DNA demethylation as well as DNA methylation, and this mechanism might account for an effect of DNMT inhibition to affect both increases and decreases in DNA methylation (Kangaspeska et al., 2008; Métivier et al., 2008).”
• DNA Demethylation Dynamics (2011, background): “…cancer cells, the promoter of the pS2/trefoil factor 1 (TFF1) gene undergoes cycles of methylation and demethylation within 20–40min in response to estrogen, demonstrating a strikingly dynamic interplay of demethylation and de novo methylation (Kangaspeska et al., 2008; Métivier et al., 2008).”