Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

By Yingxia Liu, Yang Yang, Cong Zhang, Fengming Huang, Fuxiang Wang, Jing Yuan, Zhaoqin Wang, Jinxiu Li, Jianming Li, C. Feng and 12 more. Science China Life Sciences, 2020

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The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/addeb2019aeff5d77cfe98578282fccf131d2e65

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Citations in the corpus

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• Cardiovascular complications in COVID-19 (2020, positive): “Methylprednisolone can cause electrolyte derangements, fluid retention, and hypertension [28] .”
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• Predictors of COVID-19 severity: A literature review (2020, background): “dehydrogenase (LDH), have been linked to greater disease severity.(6,9,10,20,75,81,103) Recent data suggest that LDH may be related to respiratory function and be an important predictor of respiratory failure in COVID-19 patients.”
• COVID-19, ACE2, and the cardiovascular consequences (2020, methodology): “While the major cause of mortality from COVID-19, particularly in older adults and those with compromised immune systems, is respiratory failure, a number of patients exhibit cardiovascularrelated pathologies including congestive heart failure (CHF) and brain medullary cardiorespiratory dysfunction ”
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