Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

By R. Du, Li-Rong Liang, Chengqing Yang, Wen Wang, T. Cao, Ming Li, Guangyun Guo, Juan Du, Chunlan Zheng, Qi Zhu and 4 more. European Respiratory Journal, 2020

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The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients. In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.166‒14.253; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case–control study, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 remained as predictors for high mortality from COVID-19 pneumonia. We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients. These data showed that age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 were four risk factors predicting high mortality of COVID-19 pneumonia patients https://bit.ly/2Rh6Nqv

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/66f22519effe2ce935ba6b68b482379f25f6c107

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Citations in the corpus

Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients (2021, background): “Furthermore, the combined 11 effect sizes from 11 studies [2, 10, 21, 22, 24, 28, 31, 40, 44, 51, 56] revealed significant association between obesity and coronaviruses mortality (pOR = 1.”
Biomarkers associated with COVID-19 disease progression (2020, background): “05 ng/mL as among the four risk factors predictive of mortality (age 65 years, preexisting concurrent cardiovascular or cerebrovascular diseases, CD3þCD8þ T cells ( 75 cell/ lL) [9].”
Severe obesity is associated with higher in-hospital mortality in a cohort of patientswith COVID-19 in the Bronx, New York (2020, positive): “A cohort from China revealed that obesity significantly increases the risk for developing severe pneumonia in the setting of COVID-19 (OR: 3.42; 95% CI: 1.42-8.27) [18] .”
scCODA is a Bayesian model for compositional single-cell data analysis (2021, methodology): “The correlation of T-cell abundances with severity is well established and has been used as risk factors for severe cases 22,23 .”