The Early Effect of the Roux-en-Y Gastric Bypass on Hormones Involved in Body Weight Regulation and Glucose Metabolism

By F. Rubino, M. Gagner, P. Gentileschi, S. Kini, S. Fukuyama, JOHN J. Feng, E. Diamond. Annals of Surgery, 2004

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Subfields: Surgery

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An Endocrine Society Clinical Practice Guideline Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient: (2010, background): “Bypass of the duodenum without gastric bypass or ileal interposition has been found to improve diabetes in both animal models and patients (136, 143, 147).”
The Mechanism of Diabetes Control After Gastrointestinal Bypass Surgery Reveals a Role of the Proximal Small Intestine in the Pathophysiology of Type 2 Diabetes (2006, background): “An alternative hypothesis is that the effect of selected bariatric operations on diabetes depends on exclusion of the duodenum and proximal jejunum from the transit of nutrients, possibly preventing secretion of a putative signal that promotes insulin resistance and type 2 diabetes (“foregut hypothe”
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol (2011, background): “However, the extent of change in incretins is modest, not always present in type 2 diabetes, and absent after gastric banding [40–43].”